研究実績

iMPAQT reveals that adequate mitohormesis from TFAM overexpression leads to life extension in mice

Igami K., Kittaka H., Yagi M., Gotoh K., Matsushima Y., Ide T, Ikeda M., Ueda S, Nitta S.-i., Hayakawa M., Nakayama KI., Matsumoto M., Kang D., Uchiumi T.

Life Science Alliance, 25 April 2024, DOI: 10.26508/lsa.202302498

Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy

Manabu Kodama, Gouji Toyokawa, Osamu Sugahara, Shigeaki Sugiyama, Naoki Haratake, Yuichi Yamada, Reona Wada, Shinkichi Takamori, Mototsugu Shimokawa, Tomoyoshi Takenaka, Tetsuzo Tagawa, Hiroki Kittaka, Takeshi Tsuruda, Kentaro Tanaka, Yushiro Komatsu, Keisuke Nakata, Yuri Imado, Koji Yamazaki, Isamu Okamoto, Yoshinao Oda, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyuki Shimizu, Tomoharu Yoshizumi, Keiichi I. Nakayama

Kodama et al.,2023,Cell Reports 42,112899, August 29, 2023

Extracellular vesicles expressing CEACAM proteins in the urine of bladder cancer patients.
Igami K, Uchiumi T, Shiota M, Ueda S, Tsukahara S, Akimoto M, Eto M, Kang D.
Cancer Sci. 2022 Sep;113(9):3120-3133. doi: 10.1111/cas.15438.

https://doi.org/10.1111/cas.15438

Whole Transcriptome Profiling of Adrenocortical Tumors Using Formalin-Fixed Paraffin-Embedded Samples.
Iwahashi N, Umakoshi H, Ogata M, Fukumoto T, Kaneko H, Terada E, Katsuhara S, Uchida N, Sasaki K, Yokomoto-Umakoshi M, Matsuda Y, Sakamoto R and Ogawa Y.
Frontiers in Endocrinology, 03 February 2022 : doi.org/10.3389/fendo.2022.808331

https://doi.org/10.3389/fendo.2022.808331

Oxidized Albumin and Cartilage Acidic Protein-1 as Blood Biomarkers to Predict Ischemic Stroke Outcomes.
Kuwashiro T, Tanabe K, Hayashi C, Mizoguchi T, Mori K, Jinnouchi J, Yasaka M and Okada Y.
Fronters in Neurology, 30 November 2021：doi.org/10.3389/fneur.2021.686555

https://doi.org/10.3389/fneur.2021.686555

Multiblock metabolomics: An approach to elucidate whole-body metabolism with multiblock principal component analysis.
Tanabe K, Hayashi C, Katahira T, Sasaki K, Igami K.
Computational and Structural Biotechnology Journal. 2021 Volume19:1956-1965.

Mitochondrial translation inhibition triggers ATF4 activation, leading to integrated stress response but not to mitochondrial unfolded protein response.  Sasaki K, Uchiumi T, Toshima T, Yagi M, Do Y, Hirai H, Igami K, Gotoh K, Kang D.
Bioscience reports. 2020 Nov 27;40(11). 

Comprehensive Serum Glycopeptide Spectra Analysis Combined with Artificial Intelligence (CSGSA-AI) to Diagnose Early-Stage Ovarian Cancer.    Tanabe K, Ikeda M, Hayashi M, Matsuo K, Yasaka M, Machida H, Shida M, Katahira T, Imanishi T, Hirasawa T, Sato K, Yoshida H, Mikami M.
Cancers (Basel). 2020 Aug 21;12(9):E2373. doi: 10.3390/cancers12092373.

Utility of Comprehensive Serum Glycopeptide Spectra Analysis (CSGSA) for the Detection of Early Stage Epithelial Ovarian Cancer.    Matsuo K, Tanabe K, Hayashi M, Ikeda M, Yasaka M, Machida H, Shida M, Sato K, Yoshida H, Hirasawa T, Imanishi T, Mikami M.
Cancers (Basel). 2020 Aug 21;12(9):E2374. doi: 10.3390/cancers12092374.

Regional difference in the rate of spread of SARS-CoV-2.    Tanabe K, Sasaki K, Igami K, Kamioka K.
Infect Control Hosp Epidemiol. 2020 May 11:1-2. doi: 10.1017/ice.2020.223.

Society coexisting with COVID-19.     Tanabe K.
Infect Control Hosp Epidemiol. 2020 Aug;41(8):988-989. doi: 10.1017/ice.2020.130. Epub 2020 Apr 13.

Characterization and function of medium and large extracellular vesicles from plasma and urine by surface antigens and Annexin V. PeerJ Analytical Chemistry 2:e4 2020.  Igami K, Uchiumi T, Ueda S, Kamioka K, Setoyama D, Gotoh K, Akimoto M, Matsumoto S, Kang D.

http://doi.org/10.7717/peerj-achem.4

Fully sialylated alpha-chain of complement 4-binding protein (A2160): a novel prognostic marker for epithelial ovarian carcinoma. Arch Gynecol Obstet. 2018 297(3):749-756.  Matsuo K, Tanabe K, Ikeda M, Shibata T, Kajiwara H, Miyazawa M, Miyazawa M, Hayashi M, Shida M, Hirasawa T, Roman LD, Mikami M.

UPLC-MS/MS based diagnostics for epithelial ovarian cancer using fully sialylated C4-binding protein. Biomed Chromatogr. 2017 Dec 18. doi: 10.1002/bmc.4180. Tanabe K, Matsuo K, Miyazawa M, Hayashi M, Ikeda M, Shida M, Hirasawa T, Sho R, Mikami M.

p32 is required for appropriate interleukin-6 production upon LPS stimulation and protects mice from endotoxin shock.  Sasaki K, Gotoh K, Miake S, Setoyama D, Yagi M, Igami K.
Uchiumi T, Kang D. EBioMedicine. 2017 Jun 1;20:161-72. 

Metabolomic screening using ESI-FT MS identifies potential radiation-responsive molecules in mouse urine.J. Radiat. Res. 2017 May 1;58(3):273-280.Iizuka D., Yoshioka S., Kawai H., Izumi S., Suzuki F., Kamiya K.

Multifucosylated Alpha-1-acid Glycoprotein as a Novel Marker for Hepatocellular Carcinoma. J Proteome Res. 2016 15(9):2935-44. Tanabe K, Kitagawa K, Kojima N, Iijima S.

Hepcidin-2 in mouse urine as a candidate radiation-responsive molecule.J. Radiat. Res., 2016 Mar;57(2):142-9.Iizuka D., Yoshioka S., Kawai H., Okazaki E., Kiriyama K., Izumi S., Nishimura M., Shimada Y., Kamiya K., Suzuki F.

Fully-sialylated alpha-chain of complement 4-binding protein: Diagnostic utility for ovarian clear cell carcinoma. Gynecol Oncol. 2015 139(3):520-8. Mikami M, Tanabe K, Matsuo K, Miyazaki Y, Miyazawa M, Hayashi M, Asai S, Ikeda M, Shida M, Hirasawa T, Kojima N, Sho R, Iijima S.

Performance evaluation of the new rapid fertility assays in whole blood and plasma on PATHFAST. Clin Lab. 2011;57(1-2):99-106. Sugie Y, Igami K, Shoji K, Arai N, Tazaki Y, Kouta H, Okamura Y, Tashiro S, Yokoi H.

Outer arm fucosylation of N-glycans increases in sera of hepatocellular carcinoma patients. Biochem Biophys Res Commun. 2008 374(2):219-25. Tanabe K, Deguchi A, Higashi M, Usuki H, Suzuki Y, Uchimura Y, Kuriyama S, Ikenaka K.

An N-glycan structure correlates with pulmonary metastatic ability of cancer cells. Biochem Biophys Res Commun. 2006 340(3):829-35.  Sakuma K, Fujimoto I, Hitoshi S, Tanaka F, Ikeda T, Tanabe K, Toyokuni S, Wada H, Mio T, Mishima M, Ikenaka K.

In-column removal of hydrazine and N-acetylation of oligosaccharides released by hydrazionolysis. Anal Biochem. 2006 348(2):324-6. Tanabe K, Ikenaka K.

Activation of c-Met (hepatocyte growth factor receptor) in human gastric cancer tissue. Cancer Sci. 2004 Oct;95(10):803-8. Inoue T, Kataoka H, Goto K, Nagaike K, Igami K, Naka D, Kitamura N, Miyazawa K.

Regulation of depolarization-induced calcium release from skeletal muscle triads by cyclic AMP-dependent protein kinase. Jpn J Physiol. 1999 Feb;49(1):81-7. Igami K, Yamaguchi N, Kasai M.

Kinetics of depolarization-induced calcium release from skeletal muscle triads in vitro. J Biochem. 1997 Mar;121(3):432-9. Yamaguchi N, Igami K, Kasai M.